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Alzheimer Disease News

a patient laying in a hospital bed holds hands with a healthcare provider
Research Summary
Hospital-Associated Delirium Linked to Worse Cognitive Trajectories
11/04/2026
Maria Mantas
Delirium documented within 30 days of hospitalization was associated with a significantly higher risk of mild cognitive impairment and dementia, according to longitudinal cohort findings.
Delirium documented within 30 days of hospitalization was associated with a significantly higher risk of mild cognitive impairment and dementia, according to longitudinal cohort findings.
Delirium documented within 30...
11/04/2026
Neurology
trees with leaves falling to represent dementia progression
News
Global Dementia Cases Projected to Double by 2050
10/15/2026
Maria Mantas
A meta-analysis of 38,418 participants across 18 countries or territories estimated 11.4 million new dementia cases globally in 2023, with annual incidence projected to reach 24.7 million by 2050.
A meta-analysis of 38,418 participants across 18 countries or territories estimated 11.4 million new dementia cases globally in 2023, with annual incidence projected to reach 24.7 million by 2050.
A meta-analysis of 38,418...
10/15/2026
Neurology
a researcher holds up a test tube of blood
News
Plasma p-tau217/Aβ42 Test Accuracy Reduced in Patients With Traumatic Brain Injury
07/06/2026
Maria Mantas
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio...
07/06/2026
Neurology
doctor holds hands with an older woman patient sitting on the couch
News
Higher Parity May Accelerate Preclinical Alzheimer’s Changes in Postmenopausal Women
06/29/2026
Maria Mantas
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports...
06/29/2026
Neurology
an older woman sits on a couch looking out the window
Research Summary
Frontal Release Signs Linked to Future Dementia Risk in Older Adults
06/17/2026
Maria Mantas
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release...
06/17/2026
Neurology
a man lays in bed unable to sleep
News
Accelerometer Sleep Metrics Linked to Dementia Risk in Older Adults
05/26/2026
Maria Mantas
Disruptions in sleep-wake cycles may provide scalable early markers for dementia risk in older adults, according to cohort study findings.
Disruptions in sleep-wake cycles may provide scalable early markers for dementia risk in older adults, according to cohort study findings.
Disruptions in sleep-wake cycles...
05/26/2026
Neurology
a side profile of a human head, with the top portion appearing to be made of shattered, crumpled paper
News
Plasma Biomarkers Predict Cognitive Decline in Early-Onset Dementia
05/11/2026
Maria Mantas
In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
In a South Korea–based...
05/11/2026
Neurology
an older man wearing a mask receives a vaccination shot in his upper arm
News
High-Dose Flu Vaccine Tied to Lower Alzheimer Risk
04/09/2026
Brionna Mendoza
High-dose influenza vaccination may confer additional neuroprotective benefit beyond standard-dose formulations, according to results from a new, large retrospective cohort study published in Neurology.
High-dose influenza vaccination may confer additional neuroprotective benefit beyond standard-dose formulations, according to results from a new, large retrospective cohort study published in Neurology.
High-dose influenza vaccination...
04/09/2026
Neurology
a bowl of fruits and vegetables indicates brain health
News
DASH Diet Linked to Lower Subjective Cognitive Decline Risk
03/02/2026
Maria Mantas
In a prospective cohort of 159,347 US adults, higher adherence to 6 healthy dietary patterns was associated with lower risk of subjective cognitive decline (SCD).
In a prospective cohort of 159,347 US adults, higher adherence to 6 healthy dietary patterns was associated with lower risk of subjective cognitive decline (SCD).
In a prospective cohort of...
03/02/2026
Neurology
News
Fine Particulate Air Pollution Linked to Greater Alzheimer Neuropathology, Study Finds
12/16/2025
Grace Taylor, MS, MA
Research published in JAMA Neurology links higher exposure to fine particulate air pollution (PM2.5) with more severe Alzheimer-related brain changes and faster cognitive decline in older adults.
Research published in JAMA Neurology links higher exposure to fine particulate air pollution (PM2.5) with more severe Alzheimer-related brain changes and faster cognitive decline in older adults.
Research published in JAMA...
12/16/2025
Annals of Long-Term Care

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News

a patient laying in a hospital bed holds hands with a healthcare provider
Research Summary
Hospital-Associated Delirium Linked to Worse Cognitive Trajectories
11/04/2026
Maria Mantas
Delirium documented within 30 days of hospitalization was associated with a significantly higher risk of mild cognitive impairment and dementia, according to longitudinal cohort findings.
Delirium documented within 30 days of hospitalization was associated with a significantly higher risk of mild cognitive impairment and dementia, according to longitudinal cohort findings.
Delirium documented within 30...
11/04/2026
Neurology
older adult resting hands on cane
Research Summary
Vascular Risk Factors Associated With Late-Onset Epilepsy in Older Adults
10/22/2026
Maria Mantas
Several vascular risk factors, including smoking, hypertension, diabetes and prior stroke, were associated with LOE in older adults, according to pooled analysis findings.
Several vascular risk factors, including smoking, hypertension, diabetes and prior stroke, were associated with LOE in older adults, according to pooled analysis findings.
Several vascular risk factors,...
10/22/2026
Neurology
trees with leaves falling to represent dementia progression
News
Global Dementia Cases Projected to Double by 2050
10/15/2026
Maria Mantas
A meta-analysis of 38,418 participants across 18 countries or territories estimated 11.4 million new dementia cases globally in 2023, with annual incidence projected to reach 24.7 million by 2050.
A meta-analysis of 38,418 participants across 18 countries or territories estimated 11.4 million new dementia cases globally in 2023, with annual incidence projected to reach 24.7 million by 2050.
A meta-analysis of 38,418...
10/15/2026
Neurology
a physician fills out a discharge form while speaking to a patient
Research Summary
Early Ocrelizumab Shows Sustained Long-Term Benefit in Relapsing MS
10/06/2026
Maria Mantas
Treatment with ocrelizumab for up to 10 years was associated with sustained relapse control and minimal disability accrual in patients with relapsing MS, according to phase 3 findings.
Treatment with ocrelizumab for up to 10 years was associated with sustained relapse control and minimal disability accrual in patients with relapsing MS, according to phase 3 findings.
Treatment with ocrelizumab for...
10/06/2026
Neurology
a hand points to a specific spot on a brain scan
News
P2Y12 Inhibitors Linked to Worse Intracerebral Hemorrhage Outcomes in Nationwide Study
07/13/2026
Maria Mantas
A nationwide cohort study found that prior use of P2Y12 inhibitors, either alone or combined with aspirin, was associated with more severe presentation and worse hospital outcomes in patients with spontaneous ICH.
A nationwide cohort study found that prior use of P2Y12 inhibitors, either alone or combined with aspirin, was associated with more severe presentation and worse hospital outcomes in patients with spontaneous ICH.
A nationwide cohort study found...
07/13/2026
Neurology
a researcher holds up a test tube of blood
News
Plasma p-tau217/Aβ42 Test Accuracy Reduced in Patients With Traumatic Brain Injury
07/06/2026
Maria Mantas
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio...
07/06/2026
Neurology
doctor holds hands with an older woman patient sitting on the couch
News
Higher Parity May Accelerate Preclinical Alzheimer’s Changes in Postmenopausal Women
06/29/2026
Maria Mantas
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports...
06/29/2026
Neurology
an older woman sits on a couch looking out the window
Research Summary
Frontal Release Signs Linked to Future Dementia Risk in Older Adults
06/17/2026
Maria Mantas
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release...
06/17/2026
Neurology
a doctor reviews brain scans
News
Reperfusion-Guided Blood Pressure Strategy May Improve Stroke Outcomes
06/09/2026
Maria Mantas
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized...
06/09/2026
Neurology
a strand of RNA
News
SKY-0515 Shows Sustained Biomarker Reductions in Huntington’s Disease
06/01/2026
Maria Mantas
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational...
06/01/2026
Neurology

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